Medicines to restore the liver

Preparations for liver restoration are necessary for diseases such as fatty liver, fibrosis and cirrhosis. They are also used for toxic, viral lesions, diseases of the gastrointestinal tract. In the arsenal of modern pharmacology, there are means of animal, plant and synthetic origin for the protection and restoration of hepatocytes.

When are hepatoprotectors needed?  

The liver is an organ that performs many functions in the body. This digestive gland is involved in the following processes:

1. Synthesis of plasma proteins.
2. Bile production.
3. Utilization of steroid hormones.
4. Formation of glucose from amino acids, glycerol, lactic acid and other compounds.
5. Storage of glucose in the form of glycogen.
6. Neutralization of toxic substances from the outside and from the inside (from the intestines, destroyed tissues).
7. Blood clotting.

The liver synthesizes plasma albumin, which maintains the normal osmotic pressure necessary for the circulation of fluid in the bloodstream. With hepatitis, cirrhosis, the level of this plasma protein decreases, which leads to edema.

Bile is produced for the digestion of fats, as well as the release of waste metabolites - bound hormones, bilirubin - a breakdown product of red blood cells, as well as drugs. Without normal bile production, the absorption of fat-soluble vitamins A, E, D, K is impossible.

Poor absorption of vitamin A leads to impaired vision in the dark, dryness of the conjunctiva of the eyes, and bronchial disease. Deficiency of tocopherols with poor bile secretion and stagnation of bile is manifested by muscle weakness, dysfunctions of the reproductive system.

Vitamin D is important for bones and immunity, K - for blood clotting.

The liver is involved in the neutralization and excretion of steroid hormones through the bile - cortisol, testosterone, estrogens, progesterone, aldosterone. Therefore, with hepatosis, cirrhosis, these substances will accumulate. Elevated aldosterone levels lead to edema. An increase in estrogen in the blood - to gynecological diseases, endometriosis, dysfunctional uterine bleeding, mastopathy.

How does the body signal problems in the liver?

Liver disease can manifest itself in different ways.

In acute viral hepatitis, headache, flu-like phenomena are possible, the icteric period usually begins later. Sometimes hepatitis can penetrate in the abdominal form and manifest itself as diarrhea, vomiting, and abdominal pain.

Fatty hepatosis usually does not manifest itself in any way until it turns into cirrhosis - the cells simply burst from fat, and coarse connective tissue forms at the site of their death. Non-alcoholic steatohepatitis is often combined with other diseases of the digestive system, such as pancreatitis, atrophic gastritis, etc.

The main symptoms of liver disease:

1. Yellowing of the whites of the eyes, skin.
2. Red palms.
3. Vasodilation - the appearance of spider veins.
4. Crunch in the joints, arthrosis.
5. Drowsiness, fatigue, insomnia at night.
6. Uterine, hemorrhoidal bleeding (with portal hypertension), skin bruising.
7. Depression.
8. Skin itching.
9. Stratification of nails.
10. Venous network on the abdomen, fluid in it.
11. Edema.
12. Redness of the eyes.
13. Dry skin, psoriasis, eczema.
14. Bitterness in the mouth.

A biochemical blood test for transaminases, gamma-glutamyl transpeptidase, bilirubins, bile acids and other studies will help identify the optimal drug for liver recovery.

What means to restore the liver to choose?

The liver is an organ that regenerates well, that is, it regenerates itself. This process can be helped - for this there are many drugs of various origins. They are selected by a doctor in accordance with the purpose of use and the nature of the pathology. After all, there are three syndromes of liver damage - mesenchymal inflammation, cytolytic, cholestatic.

The main preparations for the restoration of liver cells:

1. Cholagogue (Allochol, Ursofalk, Henofalk, Flamin, Tanacehol, Solhol, Gepabene, Karsil, Silymarin, Liv-52, Hofitol).
2. Phospholipids - Rezalyut, Essentiale, Phosphogliv.
3. Donators of methyl groups (Heptral, Lipoic acid, vitamin B12).
4. Hepatoprotectors with mixed action.

Cholagogue

Effective drugs to restore the liver with hypotonic dyskinesia - Tanacehol, Solhol, Flamin, Karsil, Allochol, Gepabene.

Tanacehol is a drug based on tansy. It has antispasmodic and choleretic action. It is used for digestive problems, spasm of the sphincter of Oddi, which, when relaxing, releases bile. It is also prescribed for the complex therapy of giardiasis.

Flamin is a remedy from immortelle, which, in addition to its choleretic effect, has antiseptic properties. It is used for cholecystitis. The flavonoids of the plant protect the liver from free radicals, so Flamin is a medicine to restore liver cells.

SolKhol is a remedy based on holly solyanka, which contains lohein and betaine. It has a choleretic, hepatoprotective effect. Helps restore the liver and reverse the process of fatty infiltration in alcoholic, drug, reactive hepatitis.

Karsil and Silymarin contain a plant component - milk thistle extract, which has the properties of an antioxidant and choleretic agent. The best remedy for liver restoration in Gilbert's syndrome, alcoholic and toxic hepatitis, fatty infiltration, fibrosis. Helps with fat absorption and detoxification, increases protein synthesis in the liver.

Gepabene, in addition to milk thistle, contains an extract of fumes, which has an antispasmodic effect on the sphincter of Oddi. Prevents the development of inflammation of the gallbladder and common bile duct and pain during the intake of fatty foods.

Allochol is a choleretic preparation containing an extract of garlic, nettle leaves, and ox bile. Plant components have antiseptic properties, preventing the development of putrefactive processes, flatulence, pancreatitis. Ox bile compensates for poor bile secretion and emulsifies fats, helping the pancreas to digest them with lipase.

Liv-52 is a complex preparation based on chicory, nightshade, yarrow and other choleretic herbs. Indications for use: hepatitis of toxic, viral origin, alcohol damage, taking hepatotoxic drugs.

Hofitol is the best drug for liver restoration in pregnant women. Cholagogue and diuretic from artichoke extracts. Removes edema that occurs with early and late toxicosis. Restores the glycogen-synthesizing function of the liver. Prevents the development of eclampsia.

Ursofalk (Ursosan, Urdox, Livodex, Ursoliv) is the best medicine for liver recovery in primary sclerosing cholangitis. PSC is an autoimmune disease that affects the bile ducts and leads to bile stasis. Patients feel itching, heaviness in the liver. Ursodeoxycholic acid reduces the inflammatory response due to its effect on the synthesis of antibodies to ductal cells, making bile less aggressive. Sclerosis of the bile ducts is inhibited. Symptoms of cholestasis weaken, biochemistry tests return to normal. In addition, ursocholic acid preparations are prescribed for bile reflux from the duodenum to the stomach, cholelithiasis. Bile acids help to break down stones in the ducts and bladder without resorting to surgery.

Chenofalk is a drug based on chenodeoxycholic acid. Indications: duodenogastric bile reflux, cholelithiasis, biliary dyskinesia of the hypotonic type, drug and alcohol damage to the liver cells.

Cholagogue preparations for cleansing and restoring the liver can cause diarrhea, burning, reflux, pain in the right hypochondrium.

Phospholipids

The membranes of liver cells are composed of phospholipids. Therefore, often with cytolysis syndrome, i.e. death of hepatocytes, prescribe drugs with their content. Rezalut, Essentiale, Essliver are similar in composition, but the latter contains a complex of B vitamins. Lecithins under these brands improve biochemical parameters in hepatitis, fibrosis, and fatty infiltration.

Phosphogliv is the best medicine for liver recovery in viral hepatitis A, B, C, D, E. The drug stands apart among lecithins, since it contains glycyrrhizic acid, which prevents the penetration of viruses into cells.

Methyl donators

Methylation is an important process by which new cells multiply. The restoration of liver cells is also not complete without this chemical reaction, which consists in the addition of a methyl group. Her donors help repair this important organ.

Among the donors of methyl, such means for restoring the liver are known:

1. Heptral - S-adenosylmethionine.
2. Lipoic acid - Berlition.
3. Vitamin B12 - methylcobalamin.
4. Methylfolate.

Heptral is a drug with proven clinical efficacy. The active substance is produced in the body and is used in many important biochemical transformations. With its deficiency, the level of cholesterol and homocysteine ​​​​in the blood increases (increased risk for cardiac diseases). Since S-adenosylmethionine is involved in the synthesis of neurotransmitters of the nervous system, SAMe deficiency worsens mood. Therefore, Heptral is the most effective medicine for liver restoration in depression.

Heptral in the form of injections is used in the complex therapy of hepatitis. The drug helps to improve mood. It enhances the regeneration of cartilage tissue due to participation in biochemical synthesis reactions, which is important for arthropathies accompanying liver diseases. Heptral also helps reduce an allergic reaction due to histamine methylation.

Lipoic acid, or vitamin U, is used to detoxify heavy metal poisoning. It has a positive effect on fatty hepatosis.

Conclusion

Which medicine is better for restoring the liver is decided by the attending hepatologist or gastroenterologist. Before this, a biochemical blood test, ultrasound of the liver, in some cases a biopsy and other research methods are necessary.

Preparations for the restoration of the liver - video